MLPA® - MRC Holland Kits
Please note before download:
- Mix descriptions are only free of charge for customers with maintenance contract.
- Don't hesitate to contact us, if there are any mix descriptions missing on this website.
-
To set up a new mix descriptions for you, still available at MRC Hollands website, please provide us the name of the mix (e.g. P002-D1), the version of the mix (e.g. Vs.02) and the date of its release.
- To set up a new mix descriptions for you, not available at MRC Hollands website any more, please provide us the corresponding document by email or fax (+49-7822-440150-20).
Download
- log into your SEQUENCE Pilot installation
- go to category MLPA®
- go to operation Mixes [master file]
- press button [Import] and select the downloaded mme-file
- if the corresponding mix already exists in your SEQUENE_PILOT installation you will be asked "Do you want to save the mix with a new name / lot?"; please press button [Yes] and complete the fields in the following dialogue; press button [OK] to save your entries
- if the mix doesn't exist yet just press button [OK] in the following dialogue
MIX
VERSION
DATE
REGION
APPLICATION
DOWNLOAD
MIX
ME001B
VERSION
Vs. 12
DATE
07-11-2007
REGION
various
APPLICATION
Tumor suppressor genes
MIX
ME001-C2
VERSION
Vs. 11
DATE
07-05-2012
REGION
various
APPLICATION
Tumor suppressor genes
MIX
ME002-B1
VERSION
Vs. 14
DATE
10-07-2012
REGION
various
APPLICATION
Tumor suppressor genes
MIX
ME002-C1
VERSION
Vs. 18
DATE
01-03-2013
REGION
various
APPLICATION
Tumor suppressor genes
MIX
ME004-A1
VERSION
Vs. 02
DATE
15-10-2010
REGION
various
APPLICATION
Tumor suppressor genes
MIX
ME011-B3
VERSION
Vs. 26
DATE
15-02-2017
REGION
MLH1, MSH2, MSH6, MLH3, MSH3Mismatch repair genes (MMR)
APPLICATION
Mismatch repair genes (MMR)
MIX
ME011-C1
VERSION
Vs. C1-03
DATE
23-01-2019
REGION
MLH1, MSH2, MSH6, MLH3, MSH3Mismatch repair genes (MMR)
APPLICATION
Mismatch repair genes (MMR)
MIX
ME011-D1
VERSION
Vs. D1-03
DATE
08-06-2021
REGION
MLH1 3p22.2; MSH2 2p21; MSH6 2p16.3; PMS2 7p22.1; EPCAM 2p21; BRAF V600E
APPLICATION
Mismatch repair genes
MIX
ME024-B1
VERSION
Vs. 20
DATE
07-01-2013
REGION
9p21, CDKN2A, CDKNA2B
APPLICATION
Tumours, Cutaneous melanoma
MIX
ME024-B2
VERSION
Vs. 21
DATE
29-07-2015
REGION
9p21, CDKN2A, CDKNA2B
APPLICATION
Tumours, Cutaneous melanoma
MIX
ME024-B3
VERSION
Vs. B3-02
DATE
09-06-2021
REGION
9p21: CDKN2A, CDKN2B, and flanking genes
APPLICATION
Tumours, Cutaneous melanoma
MIX
ME028-C1
VERSION
Vs. C1-03
DATE
24-01-2019
REGION
PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
APPLICATION
Prader Willi syndrome (PWS), Angelman syndrome (AS)
MIX
ME028-C1
VERSION
Vs. C1-04
DATE
06-09-2019
REGION
PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
APPLICATION
Prader Willi syndrome (PWS), Angelman syndrome (AS)
MIX
ME028-D1
VERSION
Vs. D1-01
DATE
20-07-2021
REGION
PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
APPLICATION
Prader-Willi syndrome (PWS); Angelman syndrome (AS)
MIX
ME028-D1
VERSION
Vs. D1-02
DATE
16-06-2022
REGION
PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
APPLICATION
Prader-Willi syndrome (PWS); Angelman syndrome (AS)
MIX
ME028-D1
VERSION
Vs. D1-03
DATE
21-12-2022
REGION
PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
APPLICATION
Prader-Willi syndrome (PWS); Angelman syndrome (AS)
MIX
ME030-C3
VERSION
Vs. C3-04
DATE
14-06-2019
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann Syndrome (BWS), Russell-Silver Syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-05
DATE
22-07-2019
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann Syndrome (BWS), Russell-Silver Syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-06
DATE
22-09-2020
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann Syndrome (BWS), Russell-Silver Syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-07
DATE
01-06-2021
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann syndrome (BWS); Russell-Silver syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-08
DATE
15-02-2022
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann syndrome (BWS); Russell-Silver syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-09
DATE
07-07-2022
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann syndrome (BWS); Russell-Silver syndrome (RSS)
MIX
ME030-C3
VERSION
Vs. C3-10
DATE
22-11-2022
REGION
11p15 region, H19, IGF2, CDKN1C, KCNQ1
APPLICATION
Beckwith-Wiedemann syndrome (BWS); Russell-Silver syndrome (RSS)
MIX
ME031-B2
VERSION
Vs.18
DATE
05-12-2016
REGION
GNAS 20q13.32
APPLICATION
Albright hereditary osteodystrophy (AHO), Pseudohypoparathyroidism (PHP)
MIX
ME031-B2
VERSION
Vs.19
DATE
07-06-2017
REGION
GNAS 20q13.32
APPLICATION
Albright hereditary osteodystrophy (AHO), Pseudohypoparathyroidism (PHP)
MIX
ME031-B2
VERSION
Vs.B2-01
DATE
01-09-2020
REGION
GNAS 20q13.32
APPLICATION
Albright hereditary osteodystrophy (AHO), Pseudohypoparathyroidism (PHP)
MIX
ME031-C1
VERSION
Vs.C1-01
DATE
19-03-2021
REGION
GNAS 20q13.32
APPLICATION
Albright hereditary osteodystrophy (AHO), Pseudohypoparathyroidism (PHP)
MIX
ME032-A1
VERSION
Vs. A1-01
DATE
16-02-2018
REGION
UPD7/UPD14
APPLICATION
Uniparental disomy
MIX
ME032-A1
VERSION
Vs. A1-02
DATE
19-09-2019
REGION
6q24; 7p12; 7q32; 14q32
APPLICATION
Uniparental disomy 7 (UPD7); Russel-Silver syndrome (RSS); Uniparental disomy 14 (UPD14); Temple syndrome (TS); Kagami-Ogata syndrome (KOS)
MIX
ME032-A1
VERSION
Vs. A1-03
DATE
12-01-2021
REGION
6q24; 7p12; 7q32; 14q32
APPLICATION
Uniparental disomy 7 (UPD7); Russel-Silver syndrome (RSS); Uniparental disomy 14 (UPD14); Temple syndrome (TS); Kagami-Ogata syndrome (KOS)
MIX
ME032-B1
VERSION
Vs. B1-01
DATE
20-01-2022
REGION
Chr. 7p12; 7q32; 14q32
APPLICATION
Uniparental disomy 7 (UPD7); Russel-Silver syndrome (RSS); Uniparental disomy 14 (UPD14); Temple syndrome (TS); Kagami-Ogata syndrome (KOS)
MIX
ME032-B1
VERSION
Vs. B1-03
DATE
28-06-2022
REGION
Chr. 7p12; 7q32; 14q32
APPLICATION
Uniparental disomy 7 (UPD7); Russell-Silver syndrome (RSS); Uniparental disomy 14 (UPD14); Temple syndrome (TS); Kagami-Ogata syndrome (KOS)
MIX
ME033-A1
VERSION
Vs. 04
DATE
07-06-2017
REGION
6q24
APPLICATION
Transient neonatal diabetes mellitus
MIX
ME033-A1
VERSION
Vs. A1-01
DATE
05-12-2018
REGION
6q24
APPLICATION
Transient neonatal diabetes mellitus
MIX
ME033-A1
VERSION
Vs. A1-03
DATE
24-03-2020
REGION
Chr. 6q24; 11p15
APPLICATION
Transient neonatal diabetes mellitus
MIX
ME034-B1
VERSION
Vs. B1-03
DATE
07-06-2019
REGION
various
APPLICATION
Multi-locus Imprinting / Triploidy
MIX
ME034-B1
VERSION
Vs. B1-04
DATE
06-09-2019
REGION
6q24.2; 7q32.2; 11p15.5; 14q32.2; 15q11.2; 19q13.43; 20q13.32 imprinted regions
APPLICATION
Multi-locus imprinting defects; To distinguish maternal and paternal triploidies
MIX
ME034-C1
VERSION
Vs. C1-02
DATE
31-03-2021
REGION
6q24.2; 7q32.2; 11p15.5; 14q32.2; 15q11.2; 19q13.43; 20q13.32 imprinted regions
APPLICATION
Multi-locus imprinting defects; To distinguish maternal and paternal triploidies
MIX
ME034-C1
VERSION
Vs. C1-03
DATE
26-08-2021
REGION
6q24.2; 7q32.2; 11p15.5; 14q32.2; 15q11.2; 19q13.43; 20q13.32 imprinted regions
APPLICATION
Multi-locus imprinting defects; To distinguish maternal and paternal triploidies
MIX
ME042-C1
VERSION
Vs. 09
DATE
17-02-2015
REGION
CIMP
APPLICATION
Methylation status in the CpG Island Methylator Phenotype
MIX
ME043-A1
VERSION
Vs. 04
DATE
20-12-2012
REGION
MLH1, MSH2, CDKN2A
APPLICATION
Lynch syndtrome