Service Hotline +49 7822 440150-0

MLPA® - MRC Holland Kits

Please note before download:

  • Mix descriptions are only free of charge for customers with maintenance contract.
  • Don't hesitate to contact us, if there are any mix descriptions missing on this website.

  • To set up a new mix descriptions for you, still available at MRC Hollands website, please provide us the name of the mix (e.g. P002-D1), the version of the mix (e.g. Vs.02) and the date of its release.

  • To set up a new mix descriptions for you, not available at MRC Hollands website any more, please provide us the corresponding document by email or fax (+49-7822-440150-20).

Download

  • log into your SEQUENCE Pilot installation
  • go to category MLPA®
  • go to operation Mixes [master file]
  • press button [Import] and select the downloaded mme-file
  • if the corresponding mix already exists in your SEQUENE_PILOT installation you will be asked "Do you want to save the mix with a new name / lot?"; please press button [Yes] and complete the fields in the following dialogue; press button [OK] to save your entries
  • if the mix doesn't exist yet just press button [OK] in the following dialogue
MIX
VERSION
DATE
REGION
APPLICATION
DOWNLOAD
MIX
P040-B1
VERSION
Vs. 11
DATE
11-12-2015
REGION
Various
APPLICATION
Chronic Lymphocytic Leukemia (CLL)
DOWNLOAD
MIX
P040-B2
VERSION
Vs. B2-01
DATE
26-06-2019
REGION
Various
APPLICATION
Chronic Lymphocytic Leukemia (CLL)
DOWNLOAD
MIX
P041-B1
VERSION
Vs. B1/B2-01
DATE
28-03-2017
REGION
ATM 11q23
APPLICATION
Ataxia-Telangiectasia (AT)
DOWNLOAD
MIX
P041-B1
VERSION
Vs. B1/B2-02
DATE
01-08-2018
REGION
ATM 11q23
APPLICATION
Ataxia-Telangiectasia (AT)
DOWNLOAD
MIX
P041-B1
VERSION
Vs. B1/B2-03
DATE
25-03-2021
REGION
ATM 11q22.3
APPLICATION
Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary
DOWNLOAD
MIX
P042-B2
VERSION
Vs. B1/B2-01
DATE
28-03-2017
REGION
ATM 11q23
APPLICATION
Ataxia-Telangiectasia (AT)
DOWNLOAD
MIX
P042-B2
VERSION
Vs. B1/B2-02
DATE
01-08-2018
REGION
ATM 11q23
APPLICATION
Ataxia-Telangiectasia (AT)
DOWNLOAD
MIX
P042-B2
VERSION
Vs. B1/B2-03
DATE
25-03-2021
REGION
ATM 11q22.3
APPLICATION
Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-01
DATE
25-07-2017
REGION
APC, 5q21-q22
APPLICATION
Hereditary Polyposis Colon Cancer
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-03
DATE
10-10-2019
REGION
APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
APPLICATION
Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1)
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-04
DATE
26-08-2020
REGION
APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
APPLICATION
Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1)
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-05
DATE
26-07-2021
REGION
APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
APPLICATION
Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1)
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-06
DATE
06-10-2022
REGION
APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
APPLICATION
Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1)
DOWNLOAD
MIX
P043-E1
VERSION
Vs. E1-07
DATE
24-07-2023
REGION
APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
APPLICATION
Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1)
DOWNLOAD
MIX
P044-B3
VERSION
Vs. 16
DATE
24-11-2016
REGION
NF2 22q12
APPLICATION
Neurofibromatosis type 2 (NF2)
DOWNLOAD
MIX
P044-C1
VERSION
Vs. C1-01
DATE
01-10-2019
REGION
NF2 22q12.2
APPLICATION
Neurofibromatosis type 2 (NF2)
DOWNLOAD
MIX
P044-C1
VERSION
Vs. C1-02
DATE
10-05-2021
REGION
NF2 22q12.2
APPLICATION
Neurofibromatosis type 2 (NF2)
DOWNLOAD
MIX
P044-C1
VERSION
Vs. C1-03
DATE
21-03-2022
REGION
NF2 22q12.2
APPLICATION
Neurofibromatosis type 2 (NF2)
DOWNLOAD
MIX
P045-C1
VERSION
Vs. C1-04
DATE
05-10-2018
REGION
BRCA2 13q12.3, CHEK2 22q12.1
APPLICATION
Breast cancer, hereditary
DOWNLOAD
MIX
P045-D1
VERSION
Vs. D1-01
DATE
28-05-2019
REGION
BRCA2 13q12.3, CHEK2 22q12.1
APPLICATION
Breast cancer, hereditary
DOWNLOAD
MIX
P045-D1
VERSION
Vs. D1-02
DATE
31-03-2020
REGION
BRCA2 13q13.1; CHEK2 22q12.1
APPLICATION
Breast and ovarian cancer, hereditary (HBOC); Susceptibility to breast cancer; Susceptibility to other
DOWNLOAD
MIX
P045-D1
VERSION
Vs. D1-03
DATE
06-07-2021
REGION
BRCA2 13q13.1; CHEK2 22q12.1
APPLICATION
Breast and ovarian cancer syndrome, hereditary (HBOC); Fanconi anemia type D1; Susceptibility to breast cancer; Susceptibility to other cancer types
DOWNLOAD
MIX
P045-D1
VERSION
Vs. D1-04
DATE
01-12-2022
REGION
BRCA2 13q13.1; CHEK2 22q12.1
APPLICATION
Breast and ovarian cancer syndrome, hereditary (HBOC); Fanconi anemia type D1; Susceptibility to breast cancer; Susceptibility to other cancer types
DOWNLOAD
MIX
P045-D1
VERSION
Vs. D1-05
DATE
08-06-2023
REGION
BRCA2 13q13.1; CHEK2 22q12.1
APPLICATION
Breast and ovarian cancer syndrome, hereditary (HBOC); Fanconi anemia type D1; Susceptibility to breast cancer; Susceptibility to other cancer types
DOWNLOAD
MIX
P046-C1
VERSION
Vs. C1-01
DATE
22-02-2018
REGION
TSC2 16p13.3
APPLICATION
Tuberous Sclerosis
DOWNLOAD
MIX
P046-D1
VERSION
Vs. D1-01
DATE
09-10-2019
REGION
TSC2 16p13.3
APPLICATION
Tuberous sclerosis complex (TSC)
DOWNLOAD
MIX
P046-D1
VERSION
Vs. D1-02
DATE
08-04-2021
REGION
TSC2 16p13.3
APPLICATION
Tuberous sclerosis complex (TSC)
DOWNLOAD
MIX
P046-D1
VERSION
Vs. D1-03
DATE
01-07-2022
REGION
TSC2 16p13.3
APPLICATION
Tuberous sclerosis complex (TSC)
DOWNLOAD
MIX
P047-E1
VERSION
Vs. 20
DATE
13-12-2017
REGION
RB1 13q14
APPLICATION
Retinoblastoma (RB)
DOWNLOAD
MIX
P047-E1
VERSION
Vs. 21
DATE
26-09-2019
REGION
RB1 13q14
APPLICATION
Retinoblastoma (RB)
DOWNLOAD
MIX
P047-E1
VERSION
Vs. 22
DATE
04-12-2019
REGION
RB1 13q14.2
APPLICATION
Retinoblastoma (RB)
DOWNLOAD
MIX
P047-E2
VERSION
Vs. E2-01
DATE
05-11-2021
REGION
RB1 13q14.2
APPLICATION
Retinoblastoma (RB)
DOWNLOAD
MIX
P048-C1
VERSION
Vs. 17
DATE
01-07-2016
REGION
LMNA 1q21.2-1q21.3
APPLICATION
Laminopathies, Limb-girdle muscular dystrophy, Myofibrillar myopathies
DOWNLOAD
MIX
P048-C2
VERSION
Vs. 18
DATE
21-02-2017
REGION
LMNA 1q21.2-1q21.3
APPLICATION
Laminopathies, Limb-girdle muscular dystrophy, Myofibrillar myopathies
DOWNLOAD
MIX
P048-C3
VERSION
Vs. C3-01
DATE
05-10-2020
REGION
LMNA 1q22; ZMPSTE24 1p34.2; MYOT 5q31.2; CAV3 3p25.3
APPLICATION
Laminopathies; Limb-girdle muscular dystrophy type 1A, 1B, 1C (LGMD1A/1B/1C); Emery-Dreifuss muscular dystrophy; Hutchinson-Gilford progeria syndrome; Myofibrillar myopathies
DOWNLOAD
MIX
P049-C2
VERSION
Vs. C2-01
DATE
30-04-2018
REGION
SLC6A8, Xq28
APPLICATION
Creatine transporter, x-linked
DOWNLOAD
MIX
P049-C2
VERSION
Vs. C2-02
DATE
06-06-2018
REGION
SLC6A8, Xq28
APPLICATION
Creatine transporter, x-linked
DOWNLOAD
MIX
P049-C2
VERSION
Vs. C2-03
DATE
21-09-2021
REGION
Xq28 region; SLC6A8 Xq28; ABCD1 Xq28
APPLICATION
X-linked creatine deficiency syndrome; X-linked adrenoleukodystrophy (X-ALD); X-linked
DOWNLOAD
MIX
P050-C1
VERSION
Vs. C1-02
DATE
23-01-2019
REGION
CYP21A2 6p21.3
APPLICATION
Congenital adrenal hyperplasia
DOWNLOAD
MIX
P050-C1
VERSION
Vs. C1-03
DATE
09-10-2019
REGION
CYP21A2 6p21.3
APPLICATION
Congenital adrenal hyperplasia
DOWNLOAD
MIX
P050-C1
VERSION
Vs. C1-04
DATE
01-07-2020
REGION
CYP21A2 6p21.3
APPLICATION
Congenital adrenal hyperplasia (CAH)
DOWNLOAD
MIX
P050-C1
VERSION
Vs. C1-05
DATE
01-09-2021
REGION
CYP21A2 6p21.32
APPLICATION
Congenital adrenal hyperplasia (CAH)
DOWNLOAD
MIX
P050-D1
VERSION
Vs. D1-01
DATE
06-05-2022
REGION
CYP21A2 6p21.32
APPLICATION
Congenital adrenal hyperplasia (CAH)
DOWNLOAD
MIX
P050-D1
VERSION
Vs. D1-02
DATE
24-11-2022
REGION
CYP21A2 6p21.32
APPLICATION
Congenital adrenal hyperplasia (CAH)
DOWNLOAD
MIX
P051-D1
VERSION
Vs. 27
DATE
16-01-2015
REGION
PARK2 6q25.2, SNCA 4q21, Pink1, Park7 1p36
APPLICATION
Parkinson disease, familial
DOWNLOAD
MIX
P051-D2
VERSION
Vs. D2-01
DATE
03-08-2018
REGION
PARK2 6q25.2, SNCA 4q21, Pink1, Park7 1p36
APPLICATION
Parkinson disease, familial
DOWNLOAD
MIX
P051-D2
VERSION
Vs. D2-03
DATE
09-12-2020
REGION
PARK2 6q26; SNCA 4q22.1; PINK1 1p36.12; PARK7 1p36.23; ATP13A2 1p36.13; LRRK2 12q12
APPLICATION
Parkinson disease
DOWNLOAD
MIX
P052-D1
VERSION
Vs. 27
DATE
16-01-2015
REGION
PARK2 6q25.2, SNCA 4q21, Pink1, Park7 1p36
APPLICATION
Parkinson disease, familial
DOWNLOAD
MIX
P052-D2
VERSION
Vs. D2-01
DATE
03-08-2018
REGION
PARK2 6q25.2, SNCA 4q21, Pink1, Park7 1p36
APPLICATION
Parkinson disease, familial
DOWNLOAD
MIX
P052-D2
VERSION
Vs. D2-03
DATE
09-12-2020
REGION
PARK2 6q26; UCHL1 4p13; GCH1 14q22.2; LRRK2 12q12; ATP13A2 1p36.13
APPLICATION
Parkinson disease
DOWNLOAD
MIX
P054-C1
VERSION
Vs.14
DATE
07-11-2014
REGION
FOXL2, TWIST1, FOXC1, FOXC2, ATR, PITX2, GPR143
APPLICATION
Ophthalmogenetic anomalies
DOWNLOAD
MIX
P054-C2
VERSION
Vs.16
DATE
09-08-2017
REGION
FOXL2, TWIST1, FOXC1, FOXC2, ATR, PITX2, GPR143
APPLICATION
Ophthalmogenetic anomalies
DOWNLOAD
MIX
P054-C3
VERSION
Vs.C3-01
DATE
21-07-2021
REGION
FOXL2 3q22.3; TWIST1 7p21.1; FOXC1 6p25.3; FOXC2 16q24.1; ATR 3q23; PITX2 4q25; PISRT1 3q23; GPR143 Xp22.2
APPLICATION
Ophthalmogenetic anomalies; Saethre-Chotzen syndrome (SCS); Blepharophimosis syndrome (BPES); Rieger syndrome; Ocular albinism type I
DOWNLOAD
MIX
P055-D1
VERSION
Vs. D1-02
DATE
04-04-2017
REGION
PAH 12q24.1
APPLICATION
Phenylketonuria
DOWNLOAD
MIX
P055-D1
VERSION
Vs. D1-03
DATE
17-07-2018
REGION
PAH 12q24.1
APPLICATION
Phenylketonuria
DOWNLOAD
MIX
P055-D1
VERSION
Vs. D1-04
DATE
29-06-2020
REGION
PAH 12q23.2
APPLICATION
Phenylketonuria (PKU)
DOWNLOAD
MIX
P055-D1
VERSION
Vs. D1-05
DATE
15-10-2021
REGION
PAH 12q23.2
APPLICATION
Phenylketonuria (PKU)
DOWNLOAD
MIX
P055-D1
VERSION
Vs. D1-06
DATE
25-10-2022
REGION
PAH 12q23.2
APPLICATION
Phenylketonuria (PKU)
DOWNLOAD
MIX
P056-D1
VERSION
Vs. D1-01
DATE
27-06-2018
REGION
P53 17q13.1
APPLICATION
Li-Fraumeni syndrome (LFS)
DOWNLOAD
MIX
P056-D1
VERSION
Vs. D1-02
DATE
05-10-2018
REGION
P53 17q13.1
APPLICATION
Li-Fraumeni syndrome (LFS)
DOWNLOAD
MIX
P056-D1
VERSION
Vs. D1-04
DATE
18-03-2021
REGION
TP53 17p13.1
APPLICATION
Li-Fraumeni syndrome (LFS)
DOWNLOAD
MIX
P056-D1
VERSION
Vs. D1-05
DATE
22-07-2022
REGION
TP53 17p13.1
APPLICATION
Li-Fraumeni syndrome (LFS); (Tumour analysis for research use only)
DOWNLOAD
MIX
P057-B1
VERSION
Vs. 17
DATE
21-12-2012
REGION
FANCD2. 3p25.3, PALB2 16p12
APPLICATION
Fanconi anemia (FA)
DOWNLOAD
MIX
P057-B2
VERSION
Vs. 18
DATE
24-06-2015
REGION
FANCD2. 3p25.3, PALB2 16p12
APPLICATION
Fanconi anemia (FA)
DOWNLOAD
MIX
P057-B3
VERSION
Vs. B3-01
DATE
23-06-2021
REGION
FANCD2 3p25.3; PALB2 16p12.1
APPLICATION
Fanconi anemia (FA)
DOWNLOAD
MIX
P058-A2
VERSION
Vs. 08
DATE
21-12-2012
REGION
IGHMBP2 11q13
APPLICATION
Distal spinal muscular atrophy 1 (DSMA1), SMARD1, dHMN6
DOWNLOAD
MIX
P058-A3
VERSION
Vs. 10
DATE
17-11-2016
REGION
IGHMBP2 11q13
APPLICATION
Distal spinal muscular atrophy 1 (DSMA1), SMARD1, dHMN6
DOWNLOAD
MIX
P058-A4
VERSION
Vs. A4-01
DATE
28-08-2020
REGION
IGHMBP2 11q13.3
APPLICATION
Distal spinal muscular atrophy 1 (DSMA1)
DOWNLOAD
MIX
P059-B1
VERSION
Vs. 03
DATE
04-04-2014
REGION
PRKRA; THAP1; TOR1A; ATP1A3
APPLICATION
Dystonia
DOWNLOAD
MIX
P059-B2
VERSION
Vs. B2-01
DATE
12-07-2018
REGION
PRKRA; THAP1; TOR1A; ATP1A3
APPLICATION
Dystonia
DOWNLOAD
MIX
P059-B2
VERSION
Vs. B2-02
DATE
14-12-2021
REGION
PRKRA; THAP1; TOR1A; ATP1A3
APPLICATION
Dystonia
DOWNLOAD